02 Nanoparticles for Simultaneous Cell Tracking & Microrna Delivery
نویسندگان
چکیده
منابع مشابه
Simultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles
Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...
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Experimental Section For the micellar hybrid nanoparticle (MHN) synthesis, 100 μL (MHN1), 300 μL (MHN3), or 500 μL (MHN5) of TOP-coated CdSe/ZnS or CdSexTe1-x/ZnS quantum dots (QD, Invitrogen, CA, USA) in chloroform (2 mg/mL), and 100 μL of oleic acid-coated magnetic iron oxide nanoparticles (MN, prepared using a previously reported method [1]) in chloroform (2 mg/mL), were mixed with 200 uL of...
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Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurren...
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ژورنال
عنوان ژورنال: Heart
سال: 2012
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2012-302951.002